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    Human siRNA Libraries

    Find the predefined gene family, including Druggable genes or Whole Genome, that’s right for your discovery efforts. Human siRNA libraries are available in SMARTpool or individual siRNA format for ON-TARGETplus, siGENOME and Accell technologies. Learn more about each product line to make the right choice for your experimental needs. We support more strategies for successful screening and more screening expertise than any other provider.


    Click on a collection ✔ to view availability and ordering information for that human siRNA library.

    If you have a gene list of your own not reflected in these predefined collections, click here to Submit a Quote Request for a custom siRNA library.

    Which siRNA is right for you?

    Dharmacon offers four complete pre-designed product lines across human, mouse and rat genomes. Use the table below to assist you in determining the right siRNA product line for your needs.

    Cost-effective, efficient silencing High specificity for reduced off-targets + efficient silencing Highly specific knockdown of long noncoding RNA (lncRNA) Target silencing in difficult-to-transfect cells
    siGENOME siRNA ON‑TARGETplus siRNA Lincode siRNA Accell siRNA
    Pre-designed for Human, Mouse and Rat protein-coding genes
    Pre-designed for Human and Mouse long noncoding RNA (lncRNA)
    Recommended for transfectable mammalian cells in culture
    Recommended for neuronal, suspension, primary and other difficult-to-transfect cells
    Recommended transfection reagent DharmaFECT transfection reagent DharmaFECT transfection reagent DharmaFECT transfection reagent None required
    Available as SMARTpool reagent
    Available as four individual siRNAs
    Guaranteed knockdown by SMARTpool and 3 of 4 siRNAs
    Sense strand is modified to prevent interaction with RISC and favor antisense strand uptake Selective application when thermodynamic analysis indicates it necessary for favorable antisense RISC loading
    Antisense strand seed region is modified to destabilize off-target activity and enhance target specificity
    Modifications to facilitate cellular uptake without separate transfection reagents
    Stabilizing modifications to prevent nuclease-mediated degradation
    Sequence information provided with purchase

    Resources for RNAi Screening Libraries