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Cherry-pick from our algorithm-optimized, predesigned products lines of siRNA, microRNA, and crRNA reagents to build your own custom library. Learn about cherry-pick clone libraries of shRNA or gene expression constructs.
When Dharmacon pre-defined RNAi Screening Libraries or Edit-R crRNA Libraries don't match your experimental requirements, you can make your own custom library with ease, speed and economy.
You are able to cherry-pick from our premier siRNA and microRNA product lines and Edit-R predesigned crRNA reagents for human and mouse reagents to create the ideal collection for your particular needs.
Which siRNA is right for you?
Dharmacon offers four complete pre-designed product lines across human, mouse and rat genomes. Use the table below to assist you in determining the right siRNA product line for your needs.
A mixture of 4 siRNA provided as a single reagent; providing advantages in both potency and specificity. siGENOME and ON‑TARGETplus SMARTpool are guaranteed† to silence by 75% or better.
Select 1, 2, 3 or 4 individual siRNAs† per gene.
Available for human and mouse microRNAs in miRBase v.21
Select up to 5 individual crRNAs per gene. May not be combined with RNAi products on the same plate.
†Our siRNA knockdown guarantee: siGENOME and ON‑TARGETplus siRNA reagents (SMARTpool and three of four individual siRNAs) are guaranteed to silence target gene expression by at least 75% at the mRNA level when used under optimal delivery conditions (confirmed using validated positive control and measured at the mRNA level 24 to 48 hours after transfection using 100nM siRNA).
Note: Most siGENOME and ON‑TARGETplus siRNA products are highly functional at 5 to 25nM working concentration.
Choose from three siRNA product lines, including two whole-genome collections, to find a SMARTpool or individual siRNA library suitable for your discovery efforts.
Select ON-TARGETplus for unsurpassed specificity. Select siGENOME libraries for the most up-to-date mouse siRNAs available for optimal gene target coverage.
Choose a collection of Human or Mouse siRNAs based on RefSeq lncRNA genes with NR_ Accession numbers
Mimic and Hairpin Inhibitor libraries are available for human, mouse, and rat microRNAs. Provided in 96-well plates for high-throughput phenotypic screening.
Human and mouse SMARTpool siRNA libraries in a novel pre-dispensed format to enable RNAi screening without the need for high-throughput automation.
Plated pre-defined collections of four crRNA per gene targeting popular human and mouse gene families for arrayed knockout screening
A web tool that performs complete crRNA specificity checking is introduced. In addition, we evaluated positional off-targeting of the CRISPR system.
A guide for using arrayed crRNA plates
How to use the Cherry-pick RNAi library plater for creating a custom library of RNAi reagents
Determine how much siRNA/microRNA you need for your screen
Validated Dharmacon Transfection recommendations to help you select the appropriate DharmaFECT formulation for your research
Handling and storage recommendations, resuspension recommendations, and more information for Dharmacon siRNA Libraries
General protocol for use of Dharmacon DharmaFECT transfection reagents to deliver siRNA into cultured mammalian cells
Request pricing for a catalog or Cherry-pick Library you are unable to configure online
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