siGLO Lamin A/C Control siRNA is a validated positive control, guaranteed to silence Lamin A/C in human cells. This control siRNA is chemically modified to significantly extend siRNA stability and fluorescence compared to conventional siRNAs similarly labeled with fluorophores.
Lamins are intermediate filament-type proteins, which form major components of the nuclear lamina. Lamins A and C have close sequence homology and are derived by differential splicing and alternative polyadenylation from one gene. This gene is abundantly expressed in most cells, and because it is non-essential, knockdown of the corresponding mRNA does not affect cell viability. Targets accession numbers: NM_005572, NM_170707, NM_170708(Human), NM_019390(Mouse), and NM_001002016(Rat).
Labeled with DY-547 (Cy3 analog) – Absorbance/Emission Max = 557/570nm
Significantly extended intensity of the fluorescence signal (7 days or longer)
Positive correlation of cytoplasmic fluorescence with transfection efficiency
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