siRNA-mediated RNAi experiments should include non-targeting siRNA as a control for non-sequence-specific effects. Changes in mRNA or protein levels in cells or tissues treated with these controls reflect a non-specific baseline cellular response to which the levels in cells or tissues treated with target-specific siRNA can be compared.
To request a larger quantity or in vivo processing of this control product, please email Technical Support, or call 1-800-235-9880. International customers, please call 303-604-9499 or your local Sales Representative.
The siSTABLE modification pattern dramatically extends the half-life of siRNA in the presence of 100% human serum. Unmodified siRNA degrades almost immediately while siSTABLE siRNA maintains integrity for up to 5 days.
S. Cabodi et al., p130Cas is an essential transducer element in ErbB2 transformation. FASEB J. 24(10), 3796-3808 (October 2010).