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What is guarantee for the Lincode siRNAs?
mRNAs are required to be accessible to translation machinery, and therefore accessible to RNAi as well. This is not true for lncRNAs. The ability to detect them (e.g. via NGS) does not give indication that they can be knocked down. We cannot ensure that the target is expressed and accessible to RISC machinery, which would make the siRNA appear non-functional when in fact it is an issue of the biology around the intended target.
a. Nuclear localization
b. DNA- or protein-bound RNA target
c. Secondary structure
Due to this biology, we do not guarantee the function of these reagents