If I design my own siRNA, can you synthesize it for me?
Yes, we can synthesize any siRNA in a variety of formats and scales. However, siRNAs designed using publicly available tools based solely on conventional guidelines often exhibit variable silencing efficiencies, thus requiring functional screening to identify a sufficiently potent siRNA. Our siDESIGN Center is unique among the publicly available tools a subset of the criteria employed in the advanced SMARTselection algorithm. The probability of selecting effective siRNAs is significantly improved but still requires screening for functionality. As an alternative, we can use our SMARTpool technologies which provides a functional guarantee of providing a potent siRNA silencing reagent. With this in mind, the cost of synthesizing and functionally screening multiple siRNAs from simple design tools is typically much greater than simply purchasing guaranteed SMARTselection designed pools and individual duplexes.