Can I use the Edit-R CRISPRa guide RNAs with the SAM system?

The Edit-R guide RNAs can not be used with CRISPRa systems that utilize guide RNAs modified with aptamer sequences to bring the activators to the dCas9-gRNA binding site, which is the case for the SAM system. The functionality of algorithm-designed guide RNAs is transferable between different CRISPRa systems, so the target region of an Edit-R CRISPRa guide RNA could be utilized in a guide that is designed for use with SAM.