BUB1B( Human )
BUB1 mitotic checkpoint serine/threonine kinase B
Alias
BUB1beta|BUBR1|Bub1A|MAD3L|MVA1|SSK1|hBUBR1
This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008].