P4HTM( Human )
prolyl 4-hydroxylase, transmembrane
Alias
EGLN4|HIFPH4|P4H-TM|PH-4|PH4|PHD4
The product of this gene belongs to the family of prolyl 4-hydroxylases. This protein is a prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia. It plays a role in adaptation to hypoxia and may be related to cellular oxygen sensing. Alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].