What are the purification options for your larger (greater than 1.0 umol) synthesis scales?

When purification is required above the 1 umol scale, we offer High Performance Liquid Chromatography (HPLC). For unmodified RNA oligos less than 36 nt in length, purification is typically not necessary. However, purification is recommended for most 3’ end modifications, dual label requests, internal labeling, or for long RNAs. Please contact a Technical Support Scientist at Ts.dharmacon@horizondiscovery.com for more information as to when purification is recommended.