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What is the difference between crRNAs with catalog numbers that start with CR and CM?

Our original catalog crRNA catalog numbers started with "CR". As of February 2017, chemical modifications are applied to all predesigned crRNAs to resist degradation by nucleases to improve performance in applications using co-delivery with DNA-free Cas9. You can learn more about these modifications here: http://dharmacon.horizondiscovery.com/resources/featured-articles/crrna-tracrrna-modified-cas9-mrna-protein/ Researchers who have previously purchased items with a CR- catalog number and wish to get modified crRNAs with the same design, please contact Technical Support and we can help you determine which of your old CR catalog number aligns with the new CM catalog numbers (please note, you cannot necessarily just replace the old catalog number CR with a CM to get same sequence).