PROC( Human )

Entrez Gene 5624 Entrez Gene 5624
protein C, inactivator of coagulation factors Va and VIIIa

Alias

APC|PROC1|THPH3|THPH4

This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009].

Product Category