PPP1R8( Human )

Entrez Gene 5511 Entrez Gene 5511
protein phosphatase 1 regulatory subunit 8

Alias

ARD-1|ARD1|NIPP-1|NIPP1|PRO2047

This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. [provided by RefSeq, Jul 2008].

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