PPM1B( Human )

Entrez Gene 5495 Entrez Gene 5495
protein phosphatase, Mg2+/Mn2+ dependent 1B

Alias

PP2C-beta|PP2C-beta-X|PP2CB|PP2CBETA|PPC2BETAX

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008].

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